compound gdaz 3  (MedChemExpress)

Journal: Molecules

Article Title: New Benzimidazole-Based pH-Sensitive Fluorescent Probes

doi: 10.3390/molecules30234622

Figure Lengend Snippet: Absorption and photoluminescence spectra ( λ ex = 440 nm) of compounds 3a ( a , d ), 3b ( b , e ) and 3c ( c , f ) (100 μM) in pH buffers.

Article Snippet: Compounds 3a and 3b at all concentrations studied and compound 3b at concentrations ranging from 10 −7 to 10 −5 M exhibited a weak toxic effect on cellular proteins. and (in ESI) present data on the effect of the studied substances on the biofilm biomass, the number of viable cells, and the metabolic activity of bacterial cells of the E. coli CDC F-50 and S. aureus ATCC 6538-P FDA 209-P strains.

Techniques:

Journal: Molecules

Article Title: New Benzimidazole-Based pH-Sensitive Fluorescent Probes

doi: 10.3390/molecules30234622

Figure Lengend Snippet: The dependence curve of the fluorescence intensity at the maximum on the pH and pKa value for compounds 3a ( a ), 3b ( b ), and 3c ( c ).

Article Snippet: Compounds 3a and 3b at all concentrations studied and compound 3b at concentrations ranging from 10 −7 to 10 −5 M exhibited a weak toxic effect on cellular proteins. and (in ESI) present data on the effect of the studied substances on the biofilm biomass, the number of viable cells, and the metabolic activity of bacterial cells of the E. coli CDC F-50 and S. aureus ATCC 6538-P FDA 209-P strains.

Techniques: Fluorescence

Journal: Molecules

Article Title: New Benzimidazole-Based pH-Sensitive Fluorescent Probes

doi: 10.3390/molecules30234622

Figure Lengend Snippet: Toxicity of compounds 3a – c at concentrations of 10 −8 –10 −4 M using the V. aquamarinus strain VKPM B-11245. The dotted lines in the diagram indicate the boundaries of the zones of acceptable toxicity, toxicity, and high toxicity. * Differences from the control are statistically significant, t -test; p < 0.05.

Article Snippet: Compounds 3a and 3b at all concentrations studied and compound 3b at concentrations ranging from 10 −7 to 10 −5 M exhibited a weak toxic effect on cellular proteins. and (in ESI) present data on the effect of the studied substances on the biofilm biomass, the number of viable cells, and the metabolic activity of bacterial cells of the E. coli CDC F-50 and S. aureus ATCC 6538-P FDA 209-P strains.

Techniques: Control

Journal: Molecules

Article Title: New Benzimidazole-Based pH-Sensitive Fluorescent Probes

doi: 10.3390/molecules30234622

Figure Lengend Snippet: Changes in the toxicity of compounds 3a ( a ), 3b ( b ), 3c ( c ), depending on concentrations (10 −8 –10 −4 M). The dotted line in the diagram indicates the boundary between weak and moderate toxicity. * Differences from the control are statistically significant, t -test; p < 0.05.

Article Snippet: Compounds 3a and 3b at all concentrations studied and compound 3b at concentrations ranging from 10 −7 to 10 −5 M exhibited a weak toxic effect on cellular proteins. and (in ESI) present data on the effect of the studied substances on the biofilm biomass, the number of viable cells, and the metabolic activity of bacterial cells of the E. coli CDC F-50 and S. aureus ATCC 6538-P FDA 209-P strains.

Techniques: Control

Journal: Molecules

Article Title: New Benzimidazole-Based pH-Sensitive Fluorescent Probes

doi: 10.3390/molecules30234622

Figure Lengend Snippet: The effect of compounds 3a – c on the biomass, metabolic activity, and viable cell count of bacterial biofilms of E. coli CDC F-50 and S. aureus ATCC 6538-P FDA 209-P strains, depending on concentration (10 −8 –10 −4 M). * Differences from control are statistically significant, t -test; p < 0.05.

Article Snippet: Compounds 3a and 3b at all concentrations studied and compound 3b at concentrations ranging from 10 −7 to 10 −5 M exhibited a weak toxic effect on cellular proteins. and (in ESI) present data on the effect of the studied substances on the biofilm biomass, the number of viable cells, and the metabolic activity of bacterial cells of the E. coli CDC F-50 and S. aureus ATCC 6538-P FDA 209-P strains.

Techniques: Activity Assay, Cell Counting, Concentration Assay, Control

Journal: ACS Omega

Article Title: Antimicrobial, Structural, Optical, and Redox Profiling of 7 H ‑Benzo[ c ]carbazol-10-ol Derivatives: An Integrated Experimental and Computational Study

doi: 10.1021/acsomega.5c08465

Figure Lengend Snippet: Photophysical and redox behavior of carbazole derivatives. (A) UV/vis absorption spectra of 3a – 3e in chloroform (50 μM). (B) UV/vis absorption spectra of 6a , 6b, and 7 in chloroform (50 μM). (C) UV/vis absorption spectra of 10a – 10c in chloroform (50 μM). (D) UV/vis absorption spectra of 11 and 12 in chloroform (50 μM). (E) Tauc plot of compound 3a . (F) The cyclic voltammetry profile of 3a in MeCN with n -Bu 4 NPF 6 (0.1 M) using Fc/Fc + as the internal reference.

Article Snippet: Compounds 3a – 3e (except 3d ) and 7 , which are typical 7 H -benzo [ c ] carbazol-10-ols, demonstrated good antibacterial activity against S. aureus ATCC-6538 and P. aeruginosa ATCC-9027, with inhibition zones up to 17 mm for 3e .

Techniques: